Benton Lecture 2018

Joint Meeting of Psychology Section and New York Neuropsychology Group

 Investigations of the Preclinical Stage of Alzheimer’s Disease


Date: January 8, 2018

Time: 7:00 pm



Corwin Hall

Manhattan Eye Ear and Throat Hospital

201 East 64th Street

New York NY 10065


Stephen M. Rao, PhD

Ralph and Luci Schey Endowed Chair

Professor, Cleveland Clinic Lerner College of Medicine of CWRU

Lou Ruvo Center for Brain Health

Cleveland Clinic



Neuropathological changes associated with late onset Alzheimer’s disease (AD) are thought to develop at least a decade prior to symptom onset.  Successful interventions designed to alter these early neuropathological changes during the preclinical stage can increase the probability of delaying or preventing the onset of AD.  This presentation will discuss three topics based on a series of studies conducted on healthy elders at risk for developing AD.  The first topic will report the results of a 5-year longitudinal functional and structural neuroimaging and neuropsychological study comparing cognitively intact elders with and without the APOE e4 allele.   The second topic will highlight a series of studies examining the interaction between physical activity levels and MRI/neuropsychological changes as a function of APOE e4 status.  This discussion will also describe a newly funded NIA translational grant (humans and mice subprojects) that will examine the role of immunological factors that mediate AD neuroprotection with exercise (IMMUNE-AD project).  Finally, the third topic will discuss the utility of a battery of self-administered, iPad-based, computerized cognitive tests for use in mass screening of healthy elders in the primary care clinical setting.  This approach is based on longitudinal neuropsychological studies that document a long period of gradual cognitive decline in episodic memory as well as non-memory domains during the preclinical stage of AD.


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