Benton Lecture 2018

Joint Meeting with The New York Academy of Sciences Psychology Section and New York Neuropsychology Group

 Investigations of the Preclinical Stage of Alzheimer’s Disease

 

Date: January 8, 2018

Time: 7:00 pm- 8:00pm

Registration opens at 6:30pm

 

Location:

Corwin Hall

Manhattan Eye Ear and Throat Hospital

210 East 64th Street

New York NY 10065

Stephen M. Rao, Ph.D., ABPP-Cn is the Ralph and Luci Schey Endowed Chair and Director of the Schey Center for Cognitive Neuroimaging at the Cleveland Clinic and Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He obtained his Ph.D. in Clinical Psychology from Wayne State University (Detroit) and completed a predoctoral internship at Rush-Presbyterian-St. Luke’s Medical Center (Chicago). Prior to joining the Cleveland Clinic in May of 2007, he was Director of the Functional Imaging Research Center and Professor of Neurology (Neuropsychology) at the Medical College of Wisconsin (Milwaukee). He has authored over 175 scientific papers/book chapters and edited four books. His current research areas involve the application of advanced neuroimaging techniques (task-activated and resting-state fMRI; diffusion tensor imaging) to understand the disruption of brain circuits mediating memory, attention, motor control, temporal information processing, and conceptual reasoning in normal aging and in individuals in the preclinical stage of Alzheimer’s and Huntington’s diseases, patients with multiple sclerosis, and military personnel with blast-related traumatic brain injury. More recently, his lab has developed and validated self-administered iPad-based apps for testing neuroperformance in multiple sclerosis patients and for mass screening of cognitive dysfunction in older patients attending primary care clinics. He has been a recipient of a National Institutes of Health Research Career Development Award and has received funding from the National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, National Institute on Aging, US Department of Defense, CHDI Foundation, Charles A. Dana Foundation, and National Multiple Sclerosis Society. Recently, he became principal investigator of the NIA-funded IMMUNE-AD project designed to understand immunological mechanisms underlying neuroprotection from exercise in cognitively intact older persons at genetic risk for Alzheimer’s disease. He is the Editor-in-Chief of the Journal of the International Neuropsychological Society published by Cambridge University Press and Associate Editor of American Psychologist and former Editor of Neuropsychology published by the American Psychological Association (APA), and a member of the editorial boards of eight other journals. He currently serves on the APA Publications and Communications Board and has served as President of the International Neuropsychological Society (INS), INS Board of Trustees, and Chair of the scientific program committee for the INS annual scientific meeting, as well as on the Board of Directors of the American Board of Clinical Neuropsychology. Rao CV

 

Abstract

Neuropathological changes associated with late onset Alzheimer’s disease (AD) are thought to develop at least a decade prior to symptom onset.  Successful interventions designed to alter these early neuropathological changes during the preclinical stage can increase the probability of delaying or preventing the onset of AD.  This presentation will discuss three topics based on a series of studies conducted on healthy elders at risk for developing AD.  The first topic will report the results of a 5-year longitudinal functional and structural neuroimaging and neuropsychological study comparing cognitively intact elders with and without the APOE e4 allele.   The second topic will highlight a series of studies examining the interaction between physical activity levels and MRI/neuropsychological changes as a function of APOE e4 status.  This discussion will also describe a newly funded NIA translational grant (humans and mice subprojects) that will examine the role of immunological factors that mediate AD neuroprotection with exercise (IMMUNE-AD project).  Finally, the third topic will discuss the utility of a battery of self-administered, iPad-based, computerized cognitive tests for use in mass screening of healthy elders in the primary care clinical setting.  This approach is based on longitudinal neuropsychological studies that document a long period of gradual cognitive decline in episodic memory as well as non-memory domains during the preclinical stage of AD.

 

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